Providence Genomics Releases Preliminary Geno4ME Study Findings

October 28, 2022

At Providence, our mission is health for a better world. Geno4ME supports this by providing “Genomic Medicine for EVERYONE” at multiple points of care. As a population genomics program Geno4ME provides ways to proactively screen patients so we can empower participants with knowledge to act.

Geno4ME is designed on these principles:

A Holistic, 360-Approach to Care

Geno4ME informs and supports patients and providers from pre-test to post-test. Because the novel, online e-consent and the education platform are both multi-lingual, it's easy for patients to participate, and simplifies enrollment, especially for those previously left out of genomics. For patients with a positive result, genetic counseling and pharmacist support is provided, and their physician receives educational resources and peer-to-peer support.

Pathways for Care Integration

The clinical return of results, such as reports on heritable diseases and PGx findings, are directly accessible to patients and are included in the Electronic Health Record, for physicians to access as part of their workflow. This builds a foundation for the adoption of genomic medicine across the health system.

A Whole Genome Sequencing (WGS) Platform

WGS is a forward-thinking approach that enables us to bring one-time sequencing and continued reanalysis of genomics into a wide variety of clinical applications—across many different relevant disease areas, enabling a world-class approach to genomic research. Through WGS we identify if a patient has a genetic predisposition to certain diseases and how their DNA will affect their response to certain medications.

A Focus on Diversity and Equity

Geno4ME is built on a foundation of technical innovation and excellence to ensure that we meet ALL patients where they are, identify their risk, and seamlessly deliver personalized care. Delivering “Genomic Medicine for EVERYONE,” requires conscientiously engaging underserved communities across Providence to improve health outcomes and equity.

Learn more about geno4ME.

Geno4ME Site

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Propel Genomics Site

Study Data

In the first 6 ½ months of the program, about 23,000 potential participants were outreached for Geno4ME participation. So far just over 2100 have actively consented through the online platform, of which nearly 50% self-identify as Hispanic/Latino, Asian, Black, or more than one race/ethnicity.

2100+ participants have actively consented through the online platform to date.

46.9% of participants self-identify as Hispanic/Latino, Asian, Black, or more than one race/ethnicity.

Two rectangles. The first reads: 7% of participants (83/1194) had a screen-positive result with at least one clinically actionable finding in the heritable disorder panel (pathogenic/likely pathogenic classified variant). 1 participant had two findings. The heritable disorder panel screens for genetic risk for cancer, certain cardiovascular disease, and other inherited conditions.

The second reads: 22.2% of those screen-positive participants with cancer/cardiovascular disease risk (16 out of 72) had no self-reported personal or family history of disease that met genetics referral guidelines.
What is included in the Geno4ME screening test?What are gene variants?

What's Next?

Geno4ME is still recruiting patients, and we are analyzing longitudinal data from participants to understand how their genetic results may have shaped their health and healthcare. We thank all our participants for participating in the Geno4ME study and look forward to sharing more exciting highlights soon!

Learn more about the Geno4ME program powered by Propel Genomics.